Clinical Trials and Studies

Do you have pulmonary hypertension or scleroderma? This study aims to understand how scleroderma, a skin condition, can raise the risk of pulmonary hypertension and heart failure. The study will also test whether treatments for pulmonary hypertension in people who do not have scleroderma are effective in people who have both pulmonary hypertension and scleroderma. To participate in this study, you must be at least 18 years old and must have either pulmonary hypertension or scleroderma. This study is located in Maryland.

Are you a shift worker who regularly gets 7 to 9 hours of sleep each day? This study is looking at whether shift work negatively affects overall bone health. The study will test whether resuming and maintaining a daily schedule that aligns with the environment, after a period of night shift work, can help reverse bone problems. To participate in this study, you must be 20 to 40 years old. This study takes place in Aurora, Colorado.

Are you an adult with obstructive sleep apnea? This study is examining how using continuous positive airway pressure (CPAP) to treat sleep apnea affects a person’s blood oxygen levels, heart rate, and quality of sleep. To participate in this study, you must be between 20 and 80 years old with moderate to severe obstructive sleep apnea. This study takes place in Boston, Massachusetts.

Are you an adult with sleep apnea, overweight, or obesity, or do you just want to help research? This study is looking at how sleep apnea changes fat tissue in the body. The researchers will examine whether these changes in fat tissue may raise the risk of heart and blood vessel diseases. To participate in this study, you must be between 18 and 60 years old with obstructive sleep apnea and healthy without any chronic diseases. This study takes place in Rochester, Minnesota.

Are you an adult with obstructive sleep apnea (OSA)? This study wants to understand whether mild intermittent hypoxia can help continuous positive airway pressure (CPAP) treatment work better in people who have OSA. Participants who use CPAP will be given air with low levels of oxygen for short periods during sleep. Researchers will look for improvements in OSA symptoms in people who are exposed to mild intermittent hypoxia and treated with CPAP. To participate, you must be between 18 and 60 years old. This study takes place in Detroit, Michigan.

Have you been diagnosed with obstructive sleep apnea (OSA) and been referred to the Yale New Haven Hospital Sleep Center for continuous positive airway pressure (CPAP) treatment? This study is examining how the features that can raise or lower the risk of OSA can impact how well CPAP works in an individual. Researchers will use detailed sleep studies to determine which features contribute to OSA. Results from this study will help researchers develop treatment plans that can lead to personalized OSA treatments to improve patient lives. To participate in this study, you must be at least 19 years old. This study takes place in North Haven, Connecticut.

Have you been diagnosed with a heart condition called HCM, or do you just want to help research? This study is seeking to understand how common sleep apnea is in people who have HCM. The study also wants to determine if sleep apnea is linked to problems with the rate and rhythm of the heart in people who have HCM. To participate in this study, you must be at least 18 years old. This study takes place in Rochester, Minnesota.

Are you between 14 and 22 weeks pregnant, and think that you might have obstructive sleep apnea (OSA) ? This study is testing whether using CPAP to treat obstructive sleep apnea in pregnant women can help lower the risk of hypertensive disorders during pregnancy. To participate in this study, you must be at least 18 years old. This study takes place in multiple locations in the United States.

Are you an adult who has been diagnosed with sleep apnea, prediabetes, and overweight or obesity? This study aims to understand how sleep apnea raises the risk of diabetes. The study will test whether treating sleep apnea with medicines or continuous positive airway pressure (CPAP) helps lower the risk of diabetes in people who have prediabetes. To participate in this study, you must be 20 to 65 years old. This study takes place in Chicago, Illinois.

Do you have mild sleep apnea, or do you just want to help research? This study aims to understand how mild sleep apnea and not getting enough sleep contribute to daytime sleepiness. The study will also test which of three different treatment programs is most effective at preventing daytime sleepiness. To participate in this study, you must be at least 18 years old. This study takes place in Detroit, Michigan.