Clinical Trials

Are you an adult who gets little exercise and sits a lot every day? If you sit for more than 8 hours a day and exercise less than 90 minutes per week, this study may interest you. Researchers want to see if walking or standing breaks during long sitting periods can make your heart healthier. To take part in this study, you must be 36 to 55 years old. You also should be able to walk four blocks and go up two flights of stairs. The study is taking place in Chapel Hill, North Carolina.

The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk of stroke so that appropriate and timely intervention may be administered to prevent it.

Are you an adult with carotid artery stenosis (CAS)? Researchers in this study want to learn more about the plaque that causes atherosclerosis in patients with carotid artery stenosis. To be in the study, you must be at least 18 years old and will undergo a carotid positron emission tomography (PET)/magnetic resonance imaging exam so researchers can lean more on the new PET imaging approach for risk prediction in these patients. The study is taking place Saint Louis, Missouri, and in Los Angeles, California.

Are you healthy and interested in blood flow to the brain? Too much reactive oxygen species (ROS) can lead to damage of proteins and lipids. Researchers are studying the differences in how blood flows to the brain between men and women using an oral anti-oxidant cocktail. You must be 18 to 40 years old and considered healthy to join. You will need to attend two study visits over 6 months. The study is taking place in Madison, Wisconsin.

Are you interested in how the heart and psychological conditions may be related? Researchers are looking for volunteers to participate in a study so they can learn more about how brief psychological stress affects the risk of a person having a stroke or other heart-related conditions. In this cross-sectional cohort study, participants will have their blood pressure and heart rate recorded and will undergo other tests of their heart and health, including MRI and tests of memory and attention. Participants will also take part in a brief and challenging mental task while cardiovascular activity is measured. You must be 40 to 59 years old and able to attend two study visits at the University of Pittsburgh campus in Oakland, Pennsylvania.

Did you have a stroke within the past year? Did you have a stroke within the past year? A stroke can be disabling, frequently limit functionally leading to a sedentary lifestyle and a motor disability. Exercise is one of the strategies which can help the brain to recover. This 24-week study is testing if a remotely administered behavioral intervention, called "teleABLE", reduces sedentary behavior and improves the quality of life of stroke patients. To participate in this study, you must be 18 years old or older and have access to an electronic device compatible with a videoconferencing application. This study is located in Minneapolis, Minnesota.

Are you an adult who has uncontrolled high blood pressure? This study will see whether an early notification system for health professionals can help manage patients’ high blood pressure, especially among those who have had a stroke or have an increased risk of stroke. To participate in this study, you must be between 18 and 85 years old and have high blood pressure that is not controlled by medicine and lifestyle changes. This study is enrolling native English, Spanish, or Hmong speakers. The study is located in Minneapolis, Minnesota.

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery? Did you develop atrial fibrillation after a coronary artery bypass grafting (CABG) surgery? This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). This study is in multiple locations around the country.