NHLBI COVID-19 Research Funding

The NHLBI supports various initiatives and research related to COVID-19 to help prevent, detect, and treat disease, and to improve patient outcomes.

Learn more about NHLBI's multi-pronged COVID-19 research strategy.

COVID-19 research funding opportunities

Title	Type	Expiration Date	Activity Code
Research Opportunity Announcement (ROA) for Clinical Trials for the Prevention and/or Treatment of Post-Acute Sequelae of SARS-CoV-2 infection (PASC)	Research Opportunity Announcement (ROA)
Notice of Intent to Publish a Research Opportunity Announcement (ROA) for Clinical Trials for the Prevention and/or Treatment of Post-Acute Sequelae of SARS CoV2 infection (PASC)	Research Opportunity Announcement (ROA)
Notice of Special Interest (NOSI): Stimulate Research on the Diagnosis, Treatment, and Mechanistic Understanding of Postural Orthostatic Tachycardia Syndrome (POTS)	NOSI	January 8, 2028	UG3/UH3, R01, K08, K99/R00, K01, R21, K25, K23
Notice of Special Interest (NOSI): Research on barriers to care and risk of HIV-associated comorbidities among vulnerable population groups	NOSI	May 8, 2025	R01
Notice of Special Interest (NOSI): Enhancing Research on Deciphering Mechanisms of COVID-19-Associated Coagulopathy	NOSI	July 6, 2025	R01
Notice of Special Interest (NOSI) Pediatric COVID-19 and Respiratory Viral Co-infection	NOSI	September 8, 2025	R01, R21
Expired
Notice of Special Interest (NOSI): The Influence of Host Resilience on Heterogeneity of Acute Respiratory Distress Syndrome/Acute Lung Injury (ARDS/ALI)	NOSI	July 6, 2024	R01
Notice of Special Interest (NOSI): Administrative Supplements for Research on Sex and/or Gender Influences (Admin Supp Clinical Trial Optional)	NOSI	Expired January 27, 2023	333
Notice of Special Interest (NOSI): Enhancing Research on Deciphering Mechanisms of COVID-19-Associated Coagulopathy	NOSI	Expired July 6, 2022	R01
Emergency Awards: RADx-UP - Social, Ethical, and Behavioral Implications (SEBI) Research on Disparities in COVID-19 Testing among Underserved and Vulnerable Populations (U01 Clinical Trial Optional)	Request for Application (RFA)	Expired May 3, 2022	U01
Emergency Award: RADx-UP Community-Engaged Research on Rapid SARS-CoV-2 Testing among Underserved and Vulnerable Populations (U01 Clinical Trial Optional)	RFA	Expired May 3, 2022	U01
Notice of Special Interest (NOSI): Availability of Administrative Supplements for Research on Pathobiological Mechanisms of Post-Acute Sequelae of SARS-CoV-2 Infection	NOSI	Expired January 25, 2022	333
Research to Address Vaccine Hesitancy, Uptake, and Implementation among Populations that Experience Health Disparities	NOSI	Expired January 8, 2022	R01
Researching COVID to Enhance Recovery (RECOVER) Initiative: Mobile Health Platform	Research Opportunity Announcement (ROA)	Expired July 30, 2021
REsearching COVID to Enhance Recovery (RECOVER) Initiative: Data Repositories	Research Opportunity Announcement (ROA)	Expired July 16, 2021
Availability of Urgent Competitive Revisions and Administrative Supplements for Research on Coronavirus Disease 2019 (COVID-19) in Individuals with Down Syndrome for the INCLUDE Project	NOSI	Expired July 13, 2021	Same as parent award
Emergency Award: RADx-UP - Social, Ethical, and Behavioral Implications (SEBI) Research on Disparities in COVID-19 Testing among Underserved and Vulnerable Populations	Request for Application (RFA)	Expired July 8, 2021	U01
Notice of Intent to Publish Research Opportunity Announcements for the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Initiative: PASC Data Repositories and Mobile Health Platform	Notice of Intent

Resources for COVID-19 research

For more information on future funding opportunities, visit the NHLBI and NIH funding opportunities pages regularly.
Check out NHLBI’s COVID-19 research strategy.
Find COVID-19 Information for NIH applicants and recipients of NIH funding.
See FAQs for researchers looking for COVID funding.