Host-Pathogen Dynamics

Using cutting edge imaging and spectroscopic technologies combined with novel lipidomic and proteomic approaches, investigations in the Laboratory of Host-Pathogen Dynamics, led by Dr. Nihal Altan-Bonnet, have been at the forefront of understanding the virus-host interface, revealing novel replication and transmission mechanisms shared by many different human viruses.

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Nihal Altan-Bonnet

Images

coronaviruses get out of cells using lysosomes
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Host-Pathogen Dynamics Images

How coronaviruses get out of cells using lysosomes (Ghosh et al., Cell 2020)

Electron micrograph of SARS-COV2 particles inside lysosomes
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Host-Pathogen Dynamics Images

Electron micrograph of SARS-COV2 particles inside lysosomes

viruses travel in clusters inside extracellular vesicles
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Host-Pathogen Dynamics Images

A new form of viral transmission: viruses travel in clusters inside extracellular vesicles ( Santiana et al., Cell Host and Microbe 2018)

Host lipids PI4P, cholesterol are hijacked by RNA viruses to facilitate their replication
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Host-Pathogen Dynamics Images

Host lipids PI4P, cholesterol are hijacked by RNA viruses to facilitate their replication ( Altan-Bonnet., Trends in Cell Biology 2016)

Featured Publications

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

Authors: Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, Kehrl J, Altan-Bonnet G, Altan-Bonnet N.
Cell. 2020 Oct 27;S0092-8674(20):31446-X
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Enteric viruses replicate in salivary glands and infect through saliva.

Authors: S Ghosh, M Kumar, M Santiana, A Mishra, M Zhang, H Labayo, A M Chibly, H Nakamura, T Tanaka, W Henderson, E Lewis, O Voss, Y Su, Y Belkaid, J A Chiorini, M P Hoffman, N Altan-Bonnet
Nature 2022 Jul 01;607(7918):
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Related Labs: Host-Pathogen Dynamics

Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission.

Authors: Santiana M, Ghosh S, Ho BA, Rajasekaran V, Du WL, Mutsafi Y, De Jésus-Diaz DA, Sosnovtsev SV, Levenson EA, Parra GI, Takvorian PM, Cali A, Bleck C, Vlasova AN, Saif LJ, Patton JT, Lopalco P, Corcelli A, Green KY, Altan-Bonnet N
Cell Host Microbe 2018 Aug 08;24(2):208-220
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Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses.

Authors: Chen YH, Du W, Hagemeijer MC, Takvorian PM, Pau C, Cali A, Brantner CA, Stempinski ES, Connelly PS, Ma HC, Jiang P, Wimmer E, Altan-Bonnet G, Altan-Bonnet N
Cell 2015 Feb 12;160(4):619-30
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Viral reorganization of the secretory pathway generates distinct organelles for RNA replication.

Authors: Hsu NY, Ilnytska O, Belov G, Santiana M, Chen YH, Takvorian PM, Pau C, van der Schaar H, Kaushik-Basu N, Balla T, Cameron CE, Ehrenfeld E, van Kuppeveld FJ, Altan-Bonnet N
Cell 2010 Apr 28;141(5):799-811
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Meet the Team

Nihal Altan-Bonnet

Nihal Altan-Bonnet, Ph.D.

Senior Investigator

Dr. Nihal Altan-Bonnet received her Ph.D. in cellular biophysics from The Rockefeller University. After conducting postdoctoral research with Dr. Jennifer Lippincott-Schwartz at the NIH, she joined the faculty of Rutgers University. In 2013, Dr. Altan-Bonnet returned to the NIH as an Earl Stadtman Investigator, becoming head of the Laboratory of Host-Pathogen Dynamics at the NHLBI and was promoted to tenured Senior Investigator in 2017.

Dr. Altan-Bonnet has been recognized several times for her outstanding research, including receiving the Presidential Early Career Award in Science and Engineering (PECASE) (2012), being named a Kavli Fellow of the National Academy of Sciences (2013), a Scialog Fellow of the Gordon and Betty Moore Foundation (2015-2017) and being elected to the American Academy of Microbiology (2022) and the Henry Kunkel Society (2023).

Hannah Karen

Hannah Karen Labayo, AMT, ASCPi, Ph.D.

Postdoctoral Fellow
Mamata Panigrahi

Mamata Panigrahi

Visiting Post Doc Fellow
Gunjan Arora

Gunjan Arora

Staff Scientist
Graham Brogden

Graham Brogden

Research Fellow
Kojiro Mukai

Kojiro Mukai

Research Fellow
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