Ribonucleoprotein Biochemistry

The Laboratory of Ribonucleoprotein Biochemistry, led by Dr. J. Robert Hogg, studies how RNAs attain unique functions in the cell by their intimate associations with proteins as part of ribonucleoprotein complexes (RNPs). In particular, Dr. Hogg's focus has been on quality control and RNA surveillance.

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John Hogg

Featured Publications

UPF1 mutants with intact ATPase but deficient helicase activities promote efficient nonsense-mediated mRNA decay.

Authors: Chapman JH, Craig JM, Wang CD, Gundlach JH, Neuman KC, Hogg JR.
Nucleic Acids Res. 2022 Nov 11;11(50):20
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An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decay.

Authors: Fritz SE, Ranganathan S, Wang CD, Hogg JR.
EMBO J. 2022 May 16;41(10):10
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hnRNP L-dependent protection of normal mRNAs from NMD subverts quality control in B cell lymphoma.

Authors: Kishore A, Ge Z, Hogg JR.
EMBO J. 2019 Feb 01;38(3):e99128
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ZFR coordinates crosstalk between RNA decay and transcription in innate immunity.

Authors: Haque N, Ouda R, Chen C, Ozato K, Hogg JR.
Nat Commun. 2018 Mar 20;9(1):1145
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The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay.

Authors: Fritz SE, Ranganathan S, Wang CD, Hogg JR.
J Biol Chem. 2020 Aug 14;295(33):11613-11625
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Meet the Team

John Hogg

J. Robert Hogg, Ph.D.

Senior Investigator

J. Robert Hogg graduated from Haverford College in 2000 with a B.S. in biology and earned a Ph.D. from the Department of Molecular and Cell Biology at the University of California, Berkeley in 2006. His thesis research at UC Berkeley focused on the composition and function of ribonucleoprotein complexes containing noncoding RNAs. He pursued postdoctoral research at Columbia University, where he studied mechanisms of mRNA biogenesis and quality control. He joined the NHLBI in 2012 as an Earl Stadtman tenure-track Investigator.

Contact the lab

50 South Dr
Bethesda, MD 20814
United States
Phone:
301-827-0724
Fax:
301-451-5459
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Joe Chapman, Ph.D.

Postdoctoral Fellow
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Loveth Igbineweka

Postbaccalaureate Fellow

Poonam Ghosh, Ph.D.

Postdoctoral Fellow