Obesity and Metabolic Diseases

The broad interest of the Laboratory of Obesity and Metabolic Diseases, led by Dr. Haiming Cao, is to understand the complex regulation of energy metabolism and uncover its significance in the pathogenesis of metabolic disease.

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Haiming Cao

Images

disease mutation
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Disease-causing mutation

From our lab: Disease-causing mutation.

iPS cells from our mice
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iPS cells from our mice

Mice iPS cells

iPS cells from our patients
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iPS cells from our patients

Patient iPS cells

fat lab mouse
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Our fat mouse

Mice from our lab

individual fat cell
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Our fat cell (individual)

Individual fat cells

cluster of fat cells
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Our fat cells (cluster)

A cluster of fat cells

view of lab
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View of our lab

One view of our lab

secondary view of lab
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Another view of our lab

Secondary view of the lab

lab cell culture room
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Our cell culture room

The cell culture room of our lab

nhlbi lab building
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Lab building from afar

The lab building is located at the NIH campus in Bethesda, MD.

Featured Publications

Identification of human long non-coding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis.

Authors: Ruan X, Li P, Ma Y, Jiang C, Chen Y, Shi Y, Gupta N, Seifuddin F, Pirooznia M, Ohnishi Y, Yoneda N, Nishiwaki M, Dumbovic G, Rinn JL, Higuchi Y, Kawai K, Suemizu H, Cao H.
J Clin Invest. 2020 Oct 13:136336
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In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits.

Authors: Ruan X, Li P, Chen Y, Shi Y, Pirooznia M, Seifuddin F, Suemizu H, Ohnishi Y, Yoneda N, Nishiwaki M, Shepherdson J, Suresh A, Singh K, Ma Y, Jiang CF, Cao H.
Nat Commun. 2020 Jan 02;11(1):45
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Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.

Authors: Yang L, Li P, Yang W, Ruan X, Kiesewetter K, Zhu J, Cao H
Cell Metab 2016 Oct 11;24(4):627-639
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A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting.

Authors: Ruan X, Li P, Cangelosi A, Yang L, Cao H
Cell Rep. 2016 Feb 16;S2211-1247(16):30040-7
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A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice.

Authors: Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H, Chen Y, Gucek M, Zhu J, Cao H
Cell Metab 2015 Mar 03;21(3):455-67
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Meet the Team

Haiming Cao

Haiming Cao, Ph.D.

Senior Investigator

Haiming Cao earned his Ph.D. in biochemistry in 2003 from the University of Nevada Reno. He did his postdoctoral training at Harvard University from 2003 to 2010. Dr. Cao joined the NHLBI as an Earl Stadtman Investigator in 2011.

Yonghe Ma

Yonghe Ma, Ph.D.

Postdoctoral Fellow
Cheng-fei

Cheng-fei Jiang, Ph.D.

Postdoctoral Fellow
Kaiyuan Wu, PhD

Kaiyuan Wu, Ph.D.

Staff Scientist