Obesity and Aging Research

The primary research interest of the Laboratory of Obesity and Aging Research, led by Dr. Jay H. Chung, is understanding how aging and obesity affect energy metabolism and mitochondrial function and vice versa.

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AlessioRed=mitochondria. Green=cytoplasmic mtDNA.

Featured Publications

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.

Authors: Kim J, Gupta R, Blanco LP, Yang S, Shteinfer-Kuzmine A, Wang K, Zhu J, Yoon HE, Wang X, Kerkhofs M, Kang H, Brown AL, Park SJ, Xu X, Zandee van Rilland E, Kim MK, Cohen JI, Kaplan MJ, Shoshan-Barmatz V, Chung JH.
Science 2019 Dec 20;366(6472):1531-1536
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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.

Authors: Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH
Cell 2012 Feb 03;148(3):421-33
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Peptide switch is essential for Sirt1 deacetylase activity.

Authors: Kang H, Suh JY, Jung YS, Jung JW, Kim MK, Chung JH
Mol. Cell 2011 Oct 21;44(2):203-13
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Authors: Park SJ, Gavrilova O, Brown AL, Soto JE, Bremner S, Kim J, Xu X, Yang S, Um JH, Koch LG, Britton SL, Lieber RL, Philp A, Baar K, Kohama SG, Abel ED, Kim MK, Chung JH
Cell Metab 2017 May 02;25(5):1135-1146.e7
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Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.

Authors: Kang H, Oka S, Lee DY, Park J, Aponte AM, Jung YS, Bitterman J, Zhai P, He Y, Kooshapur H, Ghirlando R, Tjandra N, Lee SB, Kim MK, Sadoshima J, Chung JH
Nat Commun 2017 May 15;8:15560
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Meet the Team

jay chung

Jay Chung, M.D., Ph.D.

Senior Investigator

Dr. Jay H. Chung earned his bachelor’s degrees in electrical engineering and computer science and biology from M.I.T. before receiving an M.D. and Ph.D. in genetics from Harvard Medical School, where he was awarded the James Tolbert Shipley Prize for Excellence in Research. After an internship and residency in internal medicine at the Brigham and Women’s Hospital, he became an endocrinology fellow at the National Institute of Diabetes and Digestive and Kidney Diseases at the NIH, where he trained with Gary Felsenfeld. He is currently a tenured senior investigator and chief of the Laboratory of Obesity and Aging Research in NHLBI. Dr. Chung has received numerous awards for his research, including the NHLBI Director’s Awards and Orloff Scientific Awards.

photo of Camille Krejkovsky

Camille Krejkovsky

Summer Intern
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