Molecular Genetics

The Laboratory of Molecular Genetics, led by Dr. Hong Xu, is pioneering mitochondrial genetics and inheritance research in the fruit fly model (Drosophila melanogaster).

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Hong Xu, Ph.D.

Featured Publications

The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster

Authors: Liu Y, Chen Z, Wang ZH, Delaney KM, Tang J, Pirooznia M, Lee DY, Tunc I, Li Y, Xu H.
Nat Cell Biol. 2022 May 01;24(5):757-765
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Mitochondrial DNA Segregation and Replication Restrict the Transmission of Detrimental Mutation

Authors: Chen Z, Wang ZH, Zhang G, Bleck CKE, Chung DJ, Madison GP, Lindberg E, Combs C, Balaban RS, Xu H.
J Cell Biol. 2020 Jul 06;219(7):e201905160
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PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations.

Authors: Zhang Y, Wang ZH, Liu Y, Chen Y, Sun N, Gucek M, Zhang F, Xu H
Mol Cell 2019 Mar 21;73(6):1127-1137
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The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication.

Authors: Zhang Y, Chen Y, Gucek M, Xu H
EMBO J 2016 Apr 06
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Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant.

Authors: Hill JH, Chen Z, Xu H
Nature genetics 2014 Apr 01;46(4):389-92
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Meet the Team

Hong Xu, Ph.D.

Hong Xu, Ph.D.

Senior Investigator

Hong Xu graduated from Nankai University with a B.S. in 1995 and received a M.S. from Peking University in 1998. He earned his Ph.D. in 2004 from the Johns Hopkins University School of Medicine, where he worked with Craig Montell. Dr. Xu did his postdoctoral fellowship at the University of California, San Francisco with Patrick O’Farrell, during which time he received the Larry L. Hillblom Postdoctoral Fellowship. Dr. Xu joined NIH a tenure-track Investigator in 2010 and was promoted to senior investigator in 2017.

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Michela Yamine

Post-baccalaureate student
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