Molecular Cell Biology

The primary research interests of the Molecular Cell Biology Laboratory, led by Dr. John A. Hammer, revolve around the roles played by motor proteins and cytoskeletal protein dynamics in driving the motility of organelles and cells.

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John Hammer

Featured Publications

A Capping Protein Regulatory Cycle Driven by CARMIL and V-1 May Promote Actin Network Assembly at Protruding Edges.

Authors: Fujiwara I, Remmert K, Piszczek G, Hammer JA.
Proc Natl Acad Sci U S A 2014 May 13;111(19):1970-9
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Nonmuscle myosin II isoforms coassemble in living cells.

Authors: Beach JR, Shao L, Remmert K, Li D, Betzig E, Hammer JA 3rd.
Curr Biol. 2014 May 19;42(10):1160-6
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Formin-Generated Actomyosin Arcs Propel T Cell Receptor Microcluster Movement at the Immune Synapse.

Authors: Murugesan S, Hong J, Yi J, Li D, Beach JR, Shao L, Meinhardt J, Madison G, Wu X, Betzig E, Hammer JA
J Cell Biol 2016 Nov 07;215(3):383-399
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Actin Dynamics and Competition for Myosin Monomer Govern the Sequential Amplification of Myosin Filaments.

Authors: Beach JR, Bruun KS, Shao L, Li D, Swider Z, Remmert K, Zhang Y, Conti MA, Adelstein RS, Rusan NM, Betzig E, Hammer JA
Nat Cell Biol 2017 Feb 01;19(2):85-93
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Myosin 18Aα targets the guanine nucleotide exchange factor β-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.

Authors: Alexander CJ, Barzik M, Fujiwara I, Remmert K, Wang YX, Petralia RS, Friedman TB, Hammer JA.
FASEB J. 2021 Jan 01;35(1):e21092
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Meet the Team

John Hammer

John Hammer, Ph.D.

Senior Investigator

John A. Hammer graduated from the Pennsylvania State University with a Ph.D. in Physiology in 1980. He then joined the NHLBI as a Staff Fellow in the Laboratory of Cell Biology. Since 1990 he has been Chief of the Section on Molecular Cell Biology, CBPC. Dr. Hammer received an NHLBI Merit Award in 1990 and an Orloff Award in 2012. He has authored or coauthored ~100 papers and has served on editorial boards, including the Journal of Muscle Research and Cell Motility (since 1992) and the Journal of Biological Chemistry (2008 to 2013). Dr. Hammer is a member of the American Society for Biochemistry and Molecular Biology, the American Society of Cell Biology, and the Biophysical Society.

Contact the lab

50 South Dr
Bethesda, MD 20814
United States
Phone:
301-496-8960
Fax:
301-402-1519

Antonio Pedrosa, Ph.D.

Postdoctoral Fellow
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