Laboratory of Critical Illness Pathogenesis and Therapeutics

The Laboratory of Critical Illness Pathogenesis and Therapeutics, led by Dr. Jeffrey Strich, focuses on understanding the pathogenesis and developing novel host-directed therapies targeting the dysregulated innate immune response that occurs during infections that cause critical illness. 

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Jeff Strich

Featured Publications

R406 reduces lipopolysaccharide-induced neutrophil activation

Authors: Seth Warner, Heather L Teague, Marcos J Ramos-Benitez, Sumith Panicker, Kiana Allen, Salina Gairhe, Tom Moyer, Bindu Parachalil Gopalan, Iyadh Douagi, Arun Shet, Yogendra Kanthi, Anthony F Suffredini, Daniel S Chertow, Jeffrey R Strich
Cellular immunology 2024 Jul 26;104860:403-404
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Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19

Authors: G. Wigerblad, S. Warner, M. Ramos-Benitez, L. Kardava, X. Tian, R. Miao, R. Reger, M. Chakraborty, S. Wong, Y. Kanthi, A. Suffredini, S. Dell'Orso, S. Brooks, C. King, O. Shlobin, S. Nathan, J. Cohen, S. Moir, R. Childs, M. Kaplan, D. Chertow, J. Strich
American Association for the Advancement of Science, issuing body 2023 Jan 04;9(1):
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Fostamatinib for the Treatment of Hospitalized Adults With Coronavirus Disease 2019: A Randomized Trial

Authors: J.Strich, X.Tian, M.Samour, C.King, O.Shlobin, R.Reger, J.Cohen, K.Ahmad, A.Brown, V.Khangoora, S.Aryal, Y.Migdady, J.Kyte, J.Joo, R.Hays, A.Collins, E.Battle, J.Valdez, J.Rivero, I.Kim, J.Erb-Alvarez, R.Shalhoub, M.Chakraborty, S.Wong, B.Colton, M.Ramos-
Infectious Diseases Society of America 2022 Aug 24;75(1):e491-e498
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Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic

Authors: Jeffrey R. Strich, Marcos J. Ramos-Benitez, Davide Randazzo, Sydney R. Stein, Ashley Babyak, Richard T. Davey, Anthony F. Suffredini, Richard W. Childs, Daniel S. Chertow
The Journal of infectious diseases 2021 Mar 29;223(6):981-984
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Assessing Clinician Utilization of Next-Generation Antibiotics Against Resistant Gram-Negative Infections in U.S. Hospitals : A Retrospective Cohort Study

Authors: Jeffrey Strich, Ahmed Mishuk, Guoqing Diao, Alexander Lawandi, Willy Li, Cumhur Demirkale, Ahmed Babiker, Alex Mancera, Bruce Swihart, Morgan Walker, Christina Yek, Maniraj Neupane, Nathaniel De Jonge, Sarah Warner, Sameer Kadri
Annals of internal medicine. 2024 May 01;177(5):559-572
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Meet the Team

Jeff Strich

Jeffrey R. Strich, MD, M.H.S.

Lasker Clinical Research Scholar, Tenure Track Investigator

Dr. Strich received his undergraduate degree from the University of Connecticut in Molecular and Cell Biology, his degree in Medicine from the Uniformed Services University of the Health Sciences, and his Masters in Health Services in Clinical Research from the Duke University School of Medicine. He completed residency training in Internal Medicine at Georgetown University Hospital and then completed a combined fellowship in Critical Care Medicine and Infectious Diseases at the National Institutes of Health.

Dr. Strich is a Medical Officer in the United States Public Health Services Commissioned Corps. Prior to pursuing his degree in Medicine he served as a Special Assistant in the Office of the Surgeon General. Dr. Strich is a member of the Infectious Disease Society of America (IDSA) the Society of Critical Care Medicine, and serves on the editorial board of Critical Care Explorations. He holds an appointment as an Adjunct Assistant Professor of Medicine at the Uniformed Services University of the Health Sciences.