Laboratory of Basic and Translational Immunology

The Laboratory of Basic and Translational Immunology, led by Dr. Parizad Torabi-Parizi, focuses on understanding innate immune cell and effector T cell behavior in peripheral tissues, mechanisms regulating such behavior.

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Parizad Torabi-Parizi, M.D.

Senior Investigator Research Interests

Research Interests

Dr. Torabi-Parizi’s program focuses on understanding innate immune cell and effector T cell behavior in peripheral tissues, mechanisms regulating such behavior, and possible interventions that might modulate these responses to improve host outcomes in the context of critical illness, with a particular emphasis on checkpoint pathways. Her current work includes establishing rodent models of sepsis and acute lung injury that allow for the evaluation of molecular mechanisms of host injury and the introduction of therapeutic interventions to alter outcomes.

Featured Publications

Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages

Authors: Curran CS, Dougherty EJ, Cui X, Li Y, Jeakle M, Gamble T, Demirkale CY, Torabi-Parizi P.
J Immunol. 2023 Jun 14:
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Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Authors: Minkove S, Dhamapurkar R, Cui X, Li Y, Sun J, Cooper D, Eichacker PQ, Torabi-Parizi P.
Intensive Care Med Exp. 2023 Apr 24;11(1):22
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Vaccination Ameliorates Cellular Inflammatory Responses in SARS-CoV-2 Breakthrough Infections.

Authors: Huapaya JA, Higgins J, Kanth S, Demirkale C, Gairhe S, Aboye EA, Regenold D, Sahagun SJ, Pastor G, Swaim D, Dewar R, Rehman T, Highbarger HC, Lallemand P, Laverdure S, Adelsberger J, Rupert A, Li W, Krack J, Teferi G, Kuruppu J, Strich JR, Davey R, Childs
J Infect Dis. 2023 Jun 28;228(1):46-58
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The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation

Authors: Kanth SM, Gairhe S, Torabi-Parizi P.
Front Immunol. 2021 May 03;12(672441):
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Anti-PD-L1 Therapy Does Not Improve Survival in a Murine Model of Lethal Staphylococcus aureus Pneumonia

Authors: Curran CS, Busch LM, Li Y, Xizhong C, Sun J, Eichacker PQ, Torabi-Parizi P.
J Infect Dis. 2021 Dec 15;224(12):2073-2084
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Meet the Team

Parizad Torabi-Parizi, M.D.

Parizad Torabi-Parizi, M.D.

Tenure Track Investigator

Dr. Parizad Torabi-Parizi earned her undergraduate degree in Chemistry and degree in Medicine from Emory University. She completed her internship and residency training in Internal Medicine at the Johns Hopkins Hospital Osler Training Program. She then completed her fellowship training in Critical Care Medicine at the NIH and is now a Tenure-Track Investigator in the NHLBI.