Laboratory of Membrane Proteins and Structural Biology

The Laboratory of Membrane Proteins and Structural Biology, led by Dr. Jiansen Jiang, studies the structures and mechanisms of some important membrane proteins, such as solute carriers, that are linked to human disease or drug transport. The lab uses biochemistry, cryo electron microscopy (cryoEM), and other tools to attack the problems, while also working on method development to expand applications of cryoEM on life sciences research.

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Jiansen Jiang

Featured Publications

Structure of Telomerase with Telomeric DNA

Authors: Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, Feigon J
Cell 2018 May 17;173(5):1179-1190
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Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex

Authors: Jiang J, Baiesc FL, Hiromasa Y, Yu X, Hui WH, Dai X, Roche TE, Zhou ZH
Biochemistry 2018 Apr 24;57(16):2325-2334
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CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

Authors: Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH, Kurtz I
Nat Commun 2018 Mar 02;9(1):900
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Structure of the yeast spliceosomal postcatalytic P complex

Authors: Liu S, Li X, Zhang L, Jiang J, Hill RC, Cui Y, Hansen KC, Zhou ZH, Zhao R
Science 2017 Dec 08;358(6368):1278-1283
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A pUL25 dimer interfaces the pseudorabies virus capsid and tegument

Authors: Liu YT, Jiang J, Bohannon KP, Dai X, Gant Luxton GW, Hui WH, Bi GQ, Smith GA, Zhou ZH
J Gen Virol 2017 Nov 01;98(11):2837-2849
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Meet the Team

Jiansen Jiang

Jiansen Jiang, Ph.D.

Investigator

Jiansen Jiang was a gold medalist of the 9th International Biology Olympiad held in Kiel, Germany in 1998. He received his B.S. in biological sciences from Tsinghua University in 2002 and Ph.D. in biophysics from Tsinghua University in 2009 in the laboratory of Sen-Fang Sui. He was a postdoctoral researcher at University of California, Los Angeles (UCLA) in the laboratory of Z. Hong Zhou from 2009 to 2017, during which time he received postdoctoral fellowships from the National Kidney Foundation serving Southern California and Southern Nevada and from the American Heart Association as well as several postdoctoral research awards from UCLA, including Chancellor’s Award for Postdoctoral Research, Parvin Foundation Award, and Sydney Finegold Award. In 2017, Dr. Jiang joined NHLBI as a Tenure-Track Investigator. Dr. Jiang is a member of the Biophysical Society.