Experimental Atherosclerosis

Research in the Laboratory of Experimental Atherosclerosis, led by Dr. Howard S. Kruth, focuses on understanding how cholesterol accumulates and plaque forms.

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Howard Kruth

Featured Publications

Macrophages Shed Excess Cholesterol in Unique Extracellular Structures Containing Cholesterol Microdomains

Authors: Jin X, Dimitriadis EK, Liu Y, Combs CA, Chang J, Varsano N, Stempinski E, Flores R, Jackson SN, Muller L, Woods AS, Addadi L, Kruth HS.
Arterioscler Thromb Vasc Biol 2018 May 31:
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Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles.

Authors: Kruth HS
Curr. Opin. Lipidol. 2011 Oct 01;22(5):386-93
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Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions.

Authors: Buono C, Anzinger JJ, Amar M, Kruth HS
J. Clin. Invest. 2009 May 01;119(5):1373-81
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Plasmin-mediated macrophage reversal of low density lipoprotein aggregation.

Authors: Zhang WY, Ishii I, Kruth HS
J. Biol. Chem. 2000 Oct 20;275(42):33176-83
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Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors.

Authors: Zhang WY, Gaynor PM, Kruth HS
J. Biol. Chem. 1996 Nov 08;271(45):28641-6
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Meet the Team

Howard Kruth

Howard S. Kruth, M.D.

Scientist Emeritus

Howard Kruth received his M.M.S. from Rutgers Medical School in 1973 and his M.D. from the University of Pennsylvania Medical School in 1975. He interned in the Department of Medicine at the University of Florida until 1976 when he joined the Laboratory of Cellular Metabolism at the NHLBI as a staff associate. Dr. Kruth returned to the University of Florida in 1978 for a residency in Clinical Pathology, and then came back to the NHLBI as Senior Investigator in the Laboratory of Experimental Atherosclerosis in 1980.  In 1988, he became the head of the Experimental Atherosclerosis Section.  Dr. Kruth has received both the Public Health Service Meritorious Service Medal in 1998 and Commendation Medal in 2004. He has authored or co-authored over 100 publications and serves on several international advisory boards.