Epigenome Biology

To study epigenetic mechanisms of development and differentiation across the mammalian genome, the Laboratory of Epigenome Biology, led by Dr. Keji Zhao, wanted a comprehensive and unbiased approach that would avoid the selection bias inherent in synthesizing probes for DNA microarrays.

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Keji Zhao

Featured Publications

O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.

Authors: Resto M, Kim BH, Fernandez AG, Abraham BJ, Zhao K, Lewis B
J Biol Chem 2016 Oct 21;291(43):22703-22713
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Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity.

Authors: Hu G, Zhao
Immunity 2016 Sep 20;45(3):459-61
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Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.

Authors: Li Y, Schulz VP, Deng C, Li G, Shen Y, Tusi BK, Ma G, Stees J, Qiu Y, Steiner LA, Zhou L, Zhao K, Bungert J, Gallagher PG, Huang
Nucleic Acids Res 2016 Sep 06;44(15):7173-88
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Global intron retention mediated gene regulation during CD4+ T cell activation.

Authors: Ni T, Yang W, Han M, Zhang Y, Shen T, Nie H, Zhou Z, Dai Y, Yang Y, Liu P, Cui K, Zeng Z, Tian Y, Zhou B, Wei G, Zhao K, Peng W, Zhu
Nucleic Acids Res 2016 Aug 19;44(14):6817-29
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Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape.

Authors: Crompton JG, Narayanan M, Cuddapah S, Roychoudhuri R, Ji Y, Yang W, Patel SJ, Sukumar M, Palmer DC, Peng W, Wang E, Marincola FM, Klebanoff CA, Zhao K, Tsang JS, Gattinoni L, Restifo N
Cell Mol Immunol 2016 Jul 01;13(4):502-13
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Meet the Team

Keji Zhao

Keji Zhao, Ph.D.

NIH Distinguished Investigator

Keji Zhao received his undergraduate degree from Changwei Normal College in Weifang, China in 1980, his M.S. degree from Northeast Normal University in Changchun, China in 1985, and his Ph.D. from the University of Geneva, Switzerland in 1996. He was a Damon Runyon-Walter Winchel Cancer Research postdoctoral fellow at Stanford University in the laboratory of Gerald Crabtree. Dr. Zhao joined the NHLBI in 1999 and was appointed a Senior Investigator in 2007 and the Director of the Systems Biology Center in 2011. He received the NIH Director’s Award in recognition of innovative contributions that have provided novel insights into epigenetic control of gene expression in 2011 and NIH Merit Awards in 2007 and 2008. Dr. Zhao also received an APAO Award for Significant Accomplishments in Biomedical Research in 2008 and was elected a Fellow of the American Association for the Advancement of Science in 2012. Dr. Zhao has authored or coauthored more than 100 papers and book chapters. He is on the editorial boards of Genome Research and Cell & Bioscience.

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