Cardiac Physiology

The Laboratory of Cardiac Physiology, led by Dr. Elizabeth Murphy, studies the molecular mechanisms involved in cardiac cell death, as well as the mechanisms that protect the heart against damage.

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Featured Publications

Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection.

Authors: Amanakis G, Sun J, Fergusson MM, McGinty S, Liu C, Molkentin JD, Murphy E.
Cardiovasc Res. 2021 Jan 01;117(1):212-223
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MICU3 Plays an Important Role in Cardiovascular Function.

Authors: Puente BN, Sun J, Parks RJ, Fergusson MM, Liu C, Springer DA, Aponte AM, Liu JC, Murphy E.
Circ Res. 2020 Dec 07;127(7):1571-1573
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Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart

Authors: Kosmach A, Roman B, Sun J, Femnou A, Zhang F, Liu C, Combs CA, Balaban RS, Murphy E.
Cell Rep. 2021 Oct 19;37(3):
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The rise in mitochondrial free Ca2+ during ischemia is suppressed but not eliminated by germline deletion of the mitochondrial Ca2+ uniporter (MCU)

Authors: Petersen, CE, Sun, J, Kosmach, A, Balaban, RS, and Murphy, E.
Cell Rep 2023 Jul 07;42(7):
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Loss of cyclophilin D prolyl isomerase activity desensitizes mitochondrial permeability transition pore opening in isolated cardiac mitochondria, but does not protect in myocardial ischemia-reperfusion injury

Authors: Casin KM, Bustamante, M, Amanakis, G, Sun, J, Liu, C, Kitsis, RN, and Murphy, E.
J. Mol. Cell Cardiol. 2023 Oct 01;183(67):
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Meet the Team

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Elizabeth Murphy, Ph.D.

Senior Investigator

Dr. Elizabeth Murphy received her PhD from the University of Pennsylvania in Biochemistry, followed by postdoctoral studies in Physiology and then an assistant research professor at Duke University Medical Center. Before joining the NHLBI in 2006 as the head of the Cardiac Physiology Section, she was the head of the Cell Biology Group at the National Institute of Environmental Health Sciences. She became a Fellow of the American Heart Association in 2001 and a Fellow of the International Society for Heart Research in 2007; she received the NHLBI Award for Outstanding Mentorship in 2011. Dr. Murphy has authored or co-authored more than 200 papers and reviews. Dr. Murphy is a member of the American Heart Association-Council of Basic Cardiovascular Research, American Physiological Society, and International Society for Heart Research. She served as president of the International Society for Heart Research from 2016 to 2019. She serves as Deputy Editor of Circulation Research. She is also the North American Coordinator of a Leducq Transatlantic Network of Excellence on Targeting Mitochondria to Treat Heart Disease.  She received the Peter Harris Research Achievement Award from the International Society for Heart Research in 2020.

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Alumni

Leslie Kennedy, Ph.D.

Independent Research Scholar

Moises Bustamante, Ph.D.

Visiting Postdoctoral Fellow