Biochemical Dynamics

Research in the Laboratory of Biochemical Dynamics involves understanding biochemical mechanisms of enzyme action and cellular regulation with a focus on the regulatory roles of reversible protein modifications.

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P. Boon Chock, Ph.D.

Featured Publications

Outer Membrane Protein OmpB Methylation May Mediate Bacterial Virulence

Authors: Yang, D.C.H., Abeykoon, A.H., Choi, B.E., Ching, W.M., and Chock, P.B.
Trends in Biochemical Sciences. 2017 Jan 01(42):936-945
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Mammalian Target of Rapamycin Complex 1 (mTORC1) Plays a Role in Pasteurella multocida Toxin (PMT)-induced Protein Synthesis and Proliferation in Swiss 3T3 Cells.

Authors: Oubrahim H, Wong A, Wilson BA, Chock PB
J Biol Chem 2013 Jan 25;288(4):2805-15
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Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation.

Authors: Mieyal JJ, Chock PB
Antioxid. Redox Signal. 2012 Mar 15;16(6):471-5
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Oxidized messenger RNA induces translation errors.

Authors: Tanaka M, Chock PB, Stadtman ER
Proc. Natl. Acad. Sci. U.S.A. 2007 Jan 02;104(1):66-71
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Kinetic method for differentiating mechanisms for ligand exchange reactions: application to test for substrate channeling in glycolysis.

Authors: Wu XM, Gutfreund H, Chock PB
Biochemistry 1992 Feb 25;31(7):2123-8
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Meet the Team

P. Boon Chock, Ph.D.

P. Boon Chock, Ph.D.

Scientist Emeritus

P. Boon Chock received his Ph.D. in Chemistry from the University of Chicago in 1967. After postdoctoral training with Manfred Eigen at the Max-Planck-Institut fȕr biophysikaliche Chemie in Göttingen, Germany, he joined the Laboratory of Biochemistry, NHLBI, NIH in 1971 as a visiting scientist, He was converted to a research scientist in 1973, and promoted to the Chief of the Metabolic Regulation Section in 1981. Dr. Chock served as the Chief of the Laboratory of Biochemistry from 1994 to 2008, and as the Director of the Biochemistry and Biophysics Center from 2002 to 2008. He received the NIH Director’s Award in 1993. Dr. Chock has authored or coauthored 200 publications, including peer-reviewed manuscripts, review articles and book chapters. Dr. Chock has served in the editorial boards of the Journal of Biological Chemistry for more than 22 years, and of the Archives of Biochemistry and Biophysics, and BioFactors. He was the co-editor of Current Topics in Cellular Regulation Series from 1989 to 2000, and of Enzyme Dynamics and Regulation. Dr. Chock is a member of the American Chemical Society and the American Society for Biochemistry and Molecular Biology.