Clinical Trials and Studies

The goal of this mechanistic clinical trial is to learn about the effects of medications called soluble guanylyl cyclase stimulators on vascular function and markers of kidney and brain injury in patients having heart surgery. This will provide important information to determine the underlying reasons that patients have some kidney and brain function problems after having heart surgery.

Do you have a Type B aortic dissection? Do you have a Type B aortic dissection? This study will compare a surgical procedure (TEVAR) followed by medical therapy to a more traditional approach using medical therapy with surveillance to determine if TEVAR can reduce complications. The TEVAR procedure is minimally-invasive. You may be able to participate if you are 18 years old or older. This study is recruiting in multiple locations.

Are you scheduled for elective cardiac surgery with cardiopulmonary bypass? Are you scheduled for elective cardiac surgery with cardiopulmonary bypass? Researchers are interested in understanding if pulsative flow during surgery can help prevent injury to the kidneys that may occasionally occur when cardiopulmonary bypass is used. You may be able to participate if you are 18 to 85 years old. This study is located in Aurora, Colorado.

Are you scheduled for open-heart surgery for your aortic valve? This study aims to look at changes in inflammation and gene activity while surgery patients are on a heart-lung bypass machine. To participate in this study, you must be at least 20 years old and be scheduled for aortic valve surgery, either with or without coronary artery bypass grafting (CABG). This study is located in Boston, Massachusetts.

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery? Did you develop atrial fibrillation after a coronary artery bypass grafting (CABG) surgery? This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). This study is in multiple locations around the country.

Are you planning to have coronary artery bypass grafting (CABG) surgery to treat your heart disease? This study aims to use computed tomography (CT) imaging to help doctors and their patients make better decisions about heart surgery. To participate in this study, you must be at least 40 years old and be scheduled for a CABG. This study is located in Palo Alto and San Diego, California