Clinical Trials and Studies

Have you been diagnosed with heart failure? This study aims to understand how heart failure develops. Researchers will identify proteins or other factors in blood that may cause decreased heart function over time. The study will require one clinical visit and you must be 18 years old or older to participate. The study is located in Bethesda, Maryland.

Are you an adult diagnosed with heart failure? Investigators are interested in better understanding right ventricular (RV) heart failure with reduced ejection fraction-related pulmonary hypertension. The study aims to improve diagnosis and description of RV heart failure. You may be able to participate if you are between 18 and 90 years old.

Do you heart failure symptoms? Symptoms may include mild shortness of breath and/or angina. This study aims to understand how the heart rate pattern due to exercise may contribute to cardiac conditioning. You are eligible to participate in this study if you are 18 years old or older and have left ventricular dysfunction.

Have you taken or will you soon be taking chemotherapy for cancer? This study is observing participants who developed chemotherapy-related cardiac toxicity (CRCT) or are susceptible to developing CRCT before chemotherapy begins. To participate in the study, you must be 18 years old or older and either have taken chemotherapy with or without CRCT diagnosis or will initiate chemotherapy. The study is located in Scottsdale, Arizona, and Jacksonville, Florida.

Do you have coronary heart disease or are you healthy and would like to participate in research? This study is comparing how well two types of magnetic resonance imaging (MRI) scanners can detect different types of heart diseases, such as coronary heart disease, heart failure, congenital heart disease, and heart valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. This study is located in Bethesda, Maryland.

Are you interested in helping researchers understand what causes heart failure? The study is using a technique called magnetic resonance spectroscopy (MRS) during a cardiac magnetic resonance imaging (MRI) scan to determine whether energy metabolism is disrupted in heart failure and whether this contributes to poor heart function. To participate in this study, you must be at least 18 years old and either be healthy or have coronary artery disease, dilated cardiomyopathy, or left ventricular hypertrophy. The study is located in Baltimore, Maryland.

Are you at least 21 years old and have heart failure? In this clinical trial, researchers want to understand why patients with heart failure have trouble exercising and doing some of their daily activities. To take part, you must be taking medication to treat your heart failure for at least 30 days. People without heart failure can also join the study. Participants will have images (MRI) taken as part of the study. The study is taking place in Baltimore, Maryland.

Do you want to help find new treatments for heart failure with preserved ejection fraction? This study is testing whether a medicine called spironolactone can help treat heart failure with preserved ejection fraction when paired with the standard treatment. Spironolactone helps to remove excess water and sodium from the body. To participate in this study, you must be between 50 and 99 years old and diagnosed with heart failure with preserved ejection fraction.

Are you able to have a magnetic resonance imaging (MRI) scan and want to help people with heart failure? This study is developing new methods for imaging the heart and blood vessels using MRI to improve how healthcare providers diagnose people with heart failure. This study takes place in Maryland and Washington, DC.

Are you an adult with heart failure and an implanted CardioMEMS pulmonary artery pressure (PAP) monitor? This study is investigating whether psychological stress can make the symptoms of heart failure worse. Participants of this study will have their blood pressure monitored and their blood drawn after undergoing mental stress in a controlled setting, within a laboratory. To participate in this study, you must be at least 18 years old. This study takes place in New Haven, Connecticut.