Population and Epidemiology Studies
Research Making a Difference
Research Making a Difference
WHY IT'S IMPORTANT
Researchers know that populations vary in their susceptibility to and resilience against heart, lung, blood, and sleep disorders, as well as in disease course and outcomes. These differences sometimes are caused by age, sex, race, ancestry or genetic factors that cannot be changed. In other cases, these differences are due to factors that can be changed or modified, such as lifestyle choices or environment, and some biological factors. Future research will help to better understand the causes of population health differences and to identify strategies that effectively address these differences before they become health disparities. Health disparities are differences in the risk, burden of diseases, and adverse health conditions that exist among specific population groups.
KEY ACCOMPLISHMENTS
- The multi-generational Framingham Heart Study helped discover risk factors and interventions to prevent heart disease, and continues to drive discovery.
- The landmark Women’s Health Initiative (WHI) found that hormone replacement therapy did not prevent heart disease as thought in post-menopausal women.
- The long-term Jackson Heart Study revealed that African Americans who took certain health measures had a lower risk for heart disease.
- The Trans-Omics for Precision Medicine (TOPMed) program is leveraging data from participants in NHLBI’s population and epidemiology studies.
OPPORTUNITIES & CHALLENGES
In 2016, the NHLBI released its Strategic Vision, which will guide the Institute’s research activities for the coming decade. Many of the objectives and compelling questions identified in the plan focus on factors that account for differences in health among populations. For example, researchers are looking at the factors that make individuals or populations resistant or prone to diseases, despite having experienced the same exposures such as diet, smoking, environmental and social factors. Part of NHLBI’s priorities include recruiting and retaining researchers who are interested in epidemiology research and developing a diverse scientific workforce.
More Information
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Population and Epidemiology Studies
Advancing the Research
Learn about some of NHLBI’s efforts to support and advance population and epidemiology research.
We Perform Research
NHLBI’s Division of Intramural Research, including its Epidemiology and Community Health Branch and Population Sciences Branch, is actively engaged in studying thousands of population cohort study participants to formulate a global view of both the natural history and future trends related to heart, lung, blood, and sleep disorders.
We Fund Research
The research we fund today will help improve our future health. Our Division of Cardiovascular Sciences’ Program in Prevention & Population Sciences, including its Epidemiology Branch and Clinical Application & Prevention Branch, supports population and epidemiology research including population studies, disease risk and outcome studies, and clinical trials to prevent disease and improve clinical care and public health. Other NHLBI Divisions also fund population and epidemiology research specific to their disease areas.
The Promise of Precision Medicine
Through NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program, researchers will use data from studies focused on heart, lung, blood and sleep disorders to better predict, prevent, diagnose, and treat diseases based on a patient’s unique genes, environment, and molecular signatures. Learn more about NHLBI precision medicine activities.
Following Cardiovascular Disease in Generations of Families
The Framingham Heart Study (FHS) is a long-term study designed to identify genetic and environmental factors influencing the development of cardiovascular and other diseases in generations of families. Through the FHS, scientists learned of the risk factors for heart disease that are now checked in all routine physicals. This study has contributed discoveries that led to major changes in the prevention and treatment of heart disease.
Leading Women’s Health Research
The Women's Health Initiative (WHI) is a long-term study focusing on strategies to prevent the major causes of death and disability among postmenopausal women. Although the original WHI study completed data collection in 2005, the WHI continues to advance women’s health through extension studies and ancillary studies, such as the Women’s Health Initiative Strong and Healthy Study (WHISH) and the Women's Health Initiative Sleep Hypoxia Effects on Resilience (WHISPER).
Informing Improvements to Clinical Care and Public Health
The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that managing high blood pressure more intensely than recommended significantly lowers the rate of cardiovascular disease and risk of death in a group of high-risk adults who are 50 years or older with high blood pressure. The SPRINT Memory and Cognition in Decreased Hypertension (SPRINT-MIND) Trial is examining whether intensive high blood pressure treatment can reduce the rate of dementia or slow the decline in cognitive function.
Investigating Atherosclerosis Causes and Outcomes
NHLBI’s Atherosclerosis Risk in Communities Study (ARIC) study is investigating the causes of atherosclerosis, a disease in which plaque builds up in the arteries, and the clinical outcomes from four U.S. communities. ARIC is also measuring how cardiovascular risk factors, medical care, and outcomes vary by race, sex, place, and time.
Examining Cardiovascular Disease Beginning in Young Adulthood
The Coronary Artery Risk Development in Young Adults (CARDIA) study examines the causes, risk factors, and natural history of cardiovascular disease that begin in young adulthood. For over 30 years, CARDIA has followed over 5,000 black and white young adults who were recruited from four centers in 1985 to 1986. The study has helped researchers better understand the importance of early adulthood factors that increase the risk of cardiovascular disease later in life.
Studying Cardiovascular Disease Outcomes
The Cardiovascular Health Study (CHS) is a long-term, population-based study of risk factors for the development of coronary heart disease and stroke in men and women aged 65 and older. Annual exams included measures of possible and proven cardiovascular disease risk, including subclinical disease.
Understanding How Diseases Impact Diverse Populations and People who love in Rural South
The NHLBI supports research to better understand the impact of diseases on minorities and to improve health outcomes in diverse populations. Studies include Hispanic Community Health Study/Study of Latinos (HCHS/SOL); Jackson Heart Study (JHS); Multi-Ethnic Study of Atherosclerosis (MESA); Strong Heart Study (SHS); The Rural Cohort Study; the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium; Consortium on Asthma among African-Ancestry Populations in the Americas (CAAPA); Healthy Communities Study: How Communities Shape Children’s Health (HCS).
Providing Access to NHLBI Biologic Specimens and Data
The Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) centralizes and integrates biospecimens and clinical data that were once stored in separate repositories. Researchers can find and request available resources on BioLINCC's secure website, which maximizes the value of these resources and advances heart, lung, blood, and sleep research.
Advancing Research on Conditions in People Living with HIV
In 2019, the NHLBI became the primary steward of the new Men’s AIDS Cohort Study (MACS) / Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS-CSS). This study is a trans-NIH collaborative research effort that aims to understand and reduce the impact of chronic health conditions that affect people living with HIV. The MACS/WIHS Combined Cohort Study will build on decades of research in thousands of men and women who are living with and without HIV to further our understanding of chronic heart, lung, blood, sleep, and other disorders in people living with HIV.
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