Bethesda, MD
Description
The National Heart, Lung, and Blood Institute, in partnership with the National Cancer Institute and Office of Disease Prevention, convened a Working Group in Bethesda, Maryland, to discuss the feasibility of and provide recommendations for testing the effects of a Mediterranean dietary pattern on cardiovascular and other disease morbidity and mortality in adults in the United States in a large lower-cost trial.
Background
In 2013, investigators of the Prevención con Dieta Mediterránea (PREDIMED) trial reported that a Mediterranean diet supplemented with extra virgin olive oil or nuts reduced the incidence of major cardiovascular events among adults at high risk. This trial, conducted in Spain, randomized 7447 men (55-80 years of age) and women (60-80 years of age) to receive either 1L/week (per family) of olive oil (50 g/day), 30g/day of mixed nuts, or small non-food gifts (control) at no cost for a median follow up of 4.8 years. The olive oil and mixed nuts group also received advice and coaching to follow a Mediterranean dietary pattern while the control group received advice to follow a low-fat diet [1]. Similarly, the Lyon Diet Heart Study found a protective effect of a Mediterranean dietary pattern on cardiac events and nonfatal acute myocardial infarction in patients with previous myocardial infarctions.
It is not known whether such a Mediterranean diet intervention could have similar profound benefits in the U.S. population. Prospective cohort studies have found strong associations between reduced CVD risk and higher adherence to a Mediterranean-style dietary pattern [2]. Randomized controlled trials and prospective cohort studies have both shown beneficial effects of Mediterranean-style dietary patterns on blood pressure and mixed effects on blood lipids [3-5]. However, no large clinical trial in the United States has assessed the benefits of a Mediterranean-style dietary pattern on cardiovascular disease morbidity and mortality.
For these reasons, the Division of Cardiovascular Sciences at NHLBI, in partnership with the NIH Office of Disease Prevention and the National Cancer Institute, convened a Working Group to discuss key challenges and opportunities for conducting lower cost clinical trials to test the effects of a Mediterranean dietary pattern on CVD and other disease morbidity and mortality in the United States.
NHLBI Contacts
Holly Nicastro, PhD, MPH
Division of Cardiovascular Sciences
holly.nicastro@nih.gov
Janet de Jesus, MS, RD
Center for Translational Research and Implementation Science
dejesusjm@nhlbi.nih.gov
Catherine (Cay) Loria, PhD, MS, MA
Division of Cardiovascular Sciences
loriac@nhlbi.nih.gov
Jacques E. Rossouw, MbChB, FCP (SA), MD
Division of Cardiovascular Sciences
rossouwj@nhlbi.nih.gov
Working Group
Co-chairs:
Penny Kris-Etherton, PhD, RD, FAHA, FNLA, FASN; The Pennsylvania State University
Frank Sacks, MD; Harvard University
Members:
Christine Albert, MD, MPH; Brigham and Women’s Hospital
Garnet Anderson, PhD; Fred Hutchinson Cancer Research Center
Lawrence J. Appel, MD, MPH; Johns Hopkins Medical Institutions
Deborah Bowen, PhD; University of Washington
John Buse, MD, PhD; University of North Carolina
Janelle W. Coughlin, PhD; Johns Hopkins School of Medicine
Alan S. Go, MD; Kaiser Permanente Northern California
Frank Hu, MD, PhD; Harvard University
Victor Kipnis, PhD; National Cancer Institute
Benoît Lamarche, PhD; Université Laval
Alice H. Lichtenstein, DSc; Tufts University
JoAnn E. Manson, MD, MPH, DrPH; Brigham and Women’s Hospital
Miguel A. Martínez González, MD, PhD, MPH; Universidad de Navarra
Robert Mentz, MD; Duke University
Martha Clare Morris, ScD; Rush University
Marian L. Neuhouser, PhD, RD; Fred Hutchinson Cancer Research Center
Ross Prentice, PhD; Fred Hutchinson Cancer Research Center
David Reboussin, PhD; Wake Forest University
Linda Van Horn, PhD, RD; Northwestern University
Mara Vitolins, DrPH, MPH, RDN, FAND; Wake Forest University
NIH Staff Planning Group
Tanya Agurs-Collins, PhD, RD; NCI
Susan Czajkowski, PhD; NCI
Kevin Dodd, PhD; NCI
Mary Evans, PhD; NIDDK
Lawrence J. Fine, MD, DrPH, FAHA; NHLBI
Stephanie George, PhD, MPH, MA; ODP
Susan Krebs-Smith, PhD, MPH; NCI
Barbara Linder, MD, PhD; NIDDK
Kathryn McMurry, MS; NHLBI
Charlotte Pratt, PhD; NHLBI
Jill Reedy, PhD, MPH, RD; NCI
Sharon Ross, PhD, MPH; NCI
Jacqueline Wright, DrPH; NHLBI
Susan Yanovski, MD; NIDDK
NIH Staff Participants
Rachel Ballard, MD, MPH; ODP
Josephine Boyington, PhD; NHLBI
Rebecca Costello, PhD; ODS
Abby Ershow, ScD, RD, FAHA; ODS
Rachel Fisher, MS, MPH, RD; NIDDK
Sheila Fleischhacker, PhD, JD; NIDDK
Kathy Helzlsouer, MD; NCI
Claudia Moy, PhD; NINDS
Nancy Potischman, PhD; ODS
Nicole Redmond, MD, PhD, MPH; NHLBI
Karen Regan, MS, RD; NIDDK
Marcel Salive, MD; NIA
Barbara Sorkin, PhD; ODS
Gina Wei, MD, MPH; NHLBI