Transplantation Immunotherapy

Research in the Laboratory of Transplantation Immunotherapy, led by Dr. Richard W. Childs, is focused on finding ways to adapt and enhance immune cells to attack even the most entrenched cancers.

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Clinical Trials and Studies

Recruiting
All Ages
All Genders
Accepting Healthy Volunteers
Do you or a child in your family have a cancerous tumor or blood disease? This study will collect blood, urine, or other samples to examine for potential new or improved treatments or prevention methods. Participants in this study must be 2 years or older and either have a cancerous tumor or a cancerous or non-cancerous blood disorder, or be a compatible family member for a stem cell transplant for the patient. This study is located at the NIH Clinical Center in Bethesda, Maryland.
RECLUTAMIENTO
Todas las edades
All
Se Aceptan Voluntaries Saludables
El objetivo de este estudio es monitorear a largo plazo la salud de los pacientes que han recibido un trasplante de células madre de donante en el Centro Clínico de los NIH. Para participar en este estudio, debe tener entre 10 y 80 años y haber recibido un trasplante con más de 3 años de anterioridad. Este estudio se lleva a cabo en Bethesda (Maryland).
Recruiting
All Ages
All Genders
Not Accepting Healthy Volunteers
Are you considering a blood stem cell transplant? This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. To participate in this study, you must have a well-matched donor; you and your donor must be between 4 and 80 years old; and you must not be a candidate for immunosuppressive therapy. This study is located in Bethesda, Maryland.
RECLUTAMIENTO
Todas las edades
All
No Se Aceptan Voluntaries Saludables
Este estudio evaluará la seguridad y la efectividad de determinados trasplantes de sangre de cordón. El estudio ayudará a los investigadores a aprender los mejores métodos para recoger, almacenar y usar sangre de cordón en los trasplantes. Para participar en este estudio, debe tener un trastorno que afecte la capacidad de su cuerpo de fabricar células sanguíneas. Este estudio se lleva a cabo en Bethesda (Maryland).
Recruiting
All Ages
All Genders
Not Accepting Healthy Volunteers
Do you or your child have severe aplastic anemia or myelodysplastic syndrome? This study aims to find new ways to make stem cell transplants safer and more effective. Researchers are testing if treating people with severe aplastic anemia with a co-infusion of blood stem cells from a family member and umbilical cord blood stem cells from an unrelated donor is safe and effective. To participate in this study, you must be between 4 and 75 years old. This study is located at the NIH Clinical Center in Bethesda, Maryland.
Recruiting
All Ages
All Genders
Not Accepting Healthy Volunteers
Do you have severe aplastic anemia, myelodysplastic syndrome, or paroxysmal nocturnal hemoglobinuria and a relative who is willing to donate blood plasma? This study is exploring whether these conditions can be treated using peripheral blood hematopoietic stem cells, which are easier to collect than bone marrow cells. To participate, you must be between 4 and 55 years old with severe aplastic anemia, myelodysplastic syndrome or paroxysmal nocturnal hemoglobinuria and have a relative who is between 4 and 75 years old who can donate peripheral blood stem cells. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Meet the Team

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Richard Childs, M.D.

Senior Investigator

Rear Admiral (RADM) Richard Childs serves as the Scientific Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He graduated from Georgetown University and Georgetown University Medical School. He completed his internship, residency, and a Chief Residency in internal medicine at the University of Florida in Gainesville followed by fellowships in Medical Oncology at the National Cancer Institute (NCI), NIH, and Hematology at the NHLBI, NIH. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI and received tenure at the NIH in 2006. He was the first investigator to show that metastatic kidney cancer could be cured by transplanted allogeneic immune cells through a graft-vs-tumor effect, a seminal discovery that was published in the New England Journal of Medicine. He continues to run a translational research lab that conducts first-in-human research in bone marrow transplantation and tumor immunotherapy. He is board certified in medical oncology, has performed more than 600 experimental bone marrow stem cell transplants at the NIH, holds more than 30 patents related to NK and T-cell based immunotherapy, and has published over 240 original research papers as the lead or senior author.

In his previous role as NHLBI Clinical Director, he directed one of the NIH’s largest clinical and translational science programs, having oversight of all of the NHLBI’s intramural research in heart, lung, and blood diseases, which includes over 250 investigator-initiated clinical trials. As Clinical Director, he spearheaded and operationalized a multi-million dollar strategic plan in 2015 that completely revamped his institute’s research infrastructure, revitalizing NHLBI’s clinical research enterprise which substantially improved and expanded its clinical research footprint and productivity.

Dr. Childs has been an active duty officer in the United Stated Commissioned Corps since 1995. He was promoted to Rear Admiral in 2015 and in 2020 received his 2nd star, and currently serves as an Assistant United States Surgeon General. In 2014, he deployed to Liberia, West Africa, as a part of the United States Ebola Crisis Response, where he served as the Chief Medical Officer caring for Ebola patients in the Monrovia Medical Unit (MMU). In 2020, he commanded a rapid response deployment team to Yokohama, Japan, that evacuated hundreds of COVID-19 infected/exposed Americans from the Diamond Princess cruise ship and provided compassionate use remdesivir for severe and critically ill passengers suffering with severe COVID-19, well before this drug received approval as a treatment for SARS-CoV-2. These actions earned him the United States Meritorious Service Medal, the Distinguished Service Medal with Valor, the Humanitarian Service and Global Health Award, and the Assistant Secretary of Health’s Exceptional Service Medal.

Stephanie

Stephanie Pierre

Postbaccalaureate Fellow
Ujjawal Savani

Ujjawal Savani

Postbaccalaureate Fellow
Stefan

Stefan Barisic, MD

Postdoctoral Fellow
Joseph

Joseph Clara, MD

Clinical Fellow
Yazan

Yazan Migdady, MD, MSc

Clinical Fellow
Larissa

Larissa Lushniak

Postbaccalaureate Fellow
Mohamed

Mohamed Samour, MD

Clinical Fellow
two members in lab

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