Laboratory of Imaging Technology

The Laboratory of Imaging Technology Program, led by Adrienne Campbell-Washburn, is focused on the development of advanced MRI techniques that leverage modern acquisition and reconstruction techniques for cardiac imaging, lung imaging and MRI-guided cardiovascular catheterization procedures.

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Adrienne

Senior Investigator Research Interests

Research Interests

The Laboratory of Imaging Technology Program, led by Dr. Adrienne Campbell-Washburn, focuses on the development of novel MRI technology for cardiac imaging, lung imaging, and MRI-guided cardiovascular catheterization procedures. The lab uses a custom high-performance 0.55T MRI system as well as clinical MRI systems. Specifically, Dr. Campbell-Washburn’s lab develops rapid non-Cartesian imaging methods, inline artifact corrections, and advanced image reconstruction methods which use contemporary computational power integrated into the clinical environment via the Gadgetron (https://github.com/gadgetron/gadgetron). The lab emphasizes translation of new methods to clinical applications through collaboration with interventional cardiologists, imaging cardiologists, pulmonologists, radiologists and critical care physicians.

Videos

Videos
Multi-section imaging of the lung using T2-weighted MRI (1.1mm x 1.1 mm x 6mm) in a woman with lymphangioleiomyomatosis resulting in innumerable thin walled pulmonary cysts. Adapted from Campbell-Washburn AE, et al, Radiology: Cardiothoracic Imaging https://doi.org/10.1148/ryct.2021200611 (Online ahead of print)
ECG-gated spiral in-out bSSFP cine imaging at 0.55T (spiral readout duration = 6.5ms, TR = 8ms). Advanced acquisition strategies increase SNR with limited artifacts at 0.55T. Adapted from Restivo MC, et al, Magn Reson Med, 2020; 84(5):2364-2375.
Interactive real-time imaging for MRI-guided cardiovascular catheterization at 0.55T. The bright gadolinium-filled balloon at the tip of the catheter is navigated in different heart chambers. Adapted from Campbell-Washburn et al, Radiology, 2019; 293(2):384-393.

Images

Late gadolinium enhancement (scar imaging) at 0.55T and 1.5T in three example patients with myocardial infarction.
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Late gadolinium enhancement (scar imaging) at 0.55T and 1.5T in three example patients with myocardial infarction.

These comparisons demonstrate diagnostic similarity between the research 0.55T MRI and clinical 1.5T MRI. Adapted from Bandettini et al, JACC: Cardiovascular Imaging, DOI: 10.1016/j.jcmg.2021.02.024 (Online ahead of print)

Measurement of regional lung function using oxygen-enhanced MRI.
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Measurement of regional lung function using oxygen-enhanced MRI.

3D stack-of-spirals ultrashort-TE imaging in a healthy volunteer during inhalation of room air versus 100% oxygen. Lung signal intensity histograms demonstrate signal enhancement on T1-weighted imaging with hyperoxia, which results in signal enhancement visible in percent enhancement maps. Adapted from Bhattacharya et al, NMR in Biomedicine, 2021;e4562 (Online ahead of print)

Clinical Trials and Studies

Desarrollo técnico de la resonancia magnética cardiovascular (RMC) mediante un sistema de escáner de baja tasa de absorción específica (SAR)

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Desarrollo de nuevas técnicas de imagen por resonancia magnética cardiovascular. Este estudio compara la eficacia de dos tipos de escáneres de resonancia magnética (RM) para detectar diferentes tipos de cardiopatías, como la cardiopatía coronaria, la insuficiencia cardíaca, las cardiopatías congénitas y las valvulopatías cardíacas. El nuevo tipo de escáner de RM de este estudio usa menos energía que un escáner tradicional y puede ser adecuado para personas que tienen dispositivos metálicos en el cuerpo. Para participar en este estudio, debe ser sano o debe tener diagnóstico de cardiopatía coronaria estable y debe tener al menos 18 años. Este estudio se lleva a cabo en Bethesda (Maryland).

Featured Publications

Efficient spiral in-out and EPI balanced steady-state free precession cine imaging using a high-performance 0.55T MRI.

Authors: Restivo MC, Ramasawmy R, Bandettini WP, Herzka DA, Campbell-Washburn AE.
Magn Reson Med. 2020 Nov 01;84(5):2364-2375
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A comparison of cine CMR imaging at 0.55 T and 1.5 T.

Authors: Bandettini WP, Shanbhag SM, Mancini C, McGuirt DR, Kellman P, Xue H, Henry JL, Lowery M, Thein SL, Chen MY, Campbell-Washburn AE.
J Cardiovasc Magn Reson. 2020 May 18;22(1):37
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Opportunities in Interventional and Diagnostic Imaging by Using High-Performance Low-Field-Strength MRI.

Authors: Campbell-Washburn AE, Ramasawmy R, Restivo MC, Bhattacharya I, Basar B, Herzka DA, Hansen MS, Rogers T, Bandettini WP, McGuirt DR, Mancini C, Grodzki D, Schneider R, Majeed W, Bhat H, Xue H, Moss J, Malayeri AA, Jones EC, Koretsky AP, Kellman P, Chen MY..
Radiology. 2019 Nov 01;293(2):384-393
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Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience.

Authors: Campbell-Washburn AE, Rogers T, Stine AM, Khan JM, Ramasawmy R, Schenke WH, McGuirt DR, Mazal JR, Grant LP, Grant EK, Herzka DA, Lederman RJ.
J Cardiovasc Magn Reson. 2018 Jun 21;20(1):41
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Real‐time distortion correction of spiral and echo planar images using the gradient system impulse response function.

Authors: Campbell-Washburn AE, Xue H, Lederman RJ, Faranesh AZ, Hansen MS.
Magn Reson Med. 2016 Jun 01;6(75):2278-85
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Meet the Team

Adrienne

Adrienne Campbell-Washburn, Ph.D.

Senior Investigator​ ​

Dr. Adrienne Campbell-Washburn graduated with her B.Sc. in physics from the University of Western Ontario (Canada), and received her PhD in Medical Physics from University College London (UK). She joined NHLBI in 2013 as a postdoctoral fellow in the Laboratory of Cardiovascular Interventions. Dr. Campbell-Washburn was appointed Staff Scientist in 2016 and director of the MR Technology Program in 2017. As of 2020, Dr. Campbell-Washburn became an Earl Stadtman Investigator in NHLBI and the chief of the MRI Technology Program. Dr. Campbell-Washburn is a Junior Fellow of the International Society for Magnetic Resonance in Medicine, a member of the Society for Cardiovascular MRI, and member of the Magnetic Resonance in Medicine editorial board. Her lab has pioneered 0.55T MRI technology for imaging the heart and lungs.

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Alumni

Burcu Basar, MSc

Engineer

Björn Wieslander, M.D., Ph.D.

Adv. Pulmonary Imaging Fellow