Cardiovascular Regenerative Medicine

The Laboratory of Cardiovascular Regenerative Medicine, led by Dr. Manfred Boehm, is focused on identifying and better understanding the molecular mechanisms underlying human vascular diseases with the goal of developing new therapeutic approaches.

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Senior Investigator Research Interests

Research Interests

The Laboratory of Cardiovascular Regenerative Medicine has established the Patient-Centered Vascular Translational Program to conduct research on clinically relevant questions focused on vascular injury, remodeling and repair, and to translate research findings into the development of new therapeutic strategies.

The aims of the Vascular Translational Program align with the principles of precision medicine, investigating how individual variations in genes, environment, and lifestyle contribute to vascular disease. This program was designed to link high-throughput sequencing data with molecular disease mechanisms to facilitate the development of targeted therapies and through this program, we have already successfully identified the genetic cause and/or underlying mechanism of a variety of rare diseases. We are particularly interested in investigating the mechanisms of vascular remodeling triggered by injury or other perturbations such as dysregulated homeostasis, inflammation, calcification or endothelial dysfunction. We believe that improving our understanding of these processes will help us find solutions for disease mitigation and restoring the balance of the relevant biological processes.

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Research Interests

Clinical Trials and Studies

Protocolo para el descubrimiento de la enfermedad vascular

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Comprender las enfermedades del corazón y los vasos sanguíneos El objetivo de este estudio es recabar datos y obtener muestras de personas que tienen enfermedad cardíaca o de los vasos sanguíneos, incluida PAD. Esto puede incluir análisis de sangre, exámenes ecográficos y pruebas cardíacas y pulmonares. Los familiares y las personas sanas también pueden participar. Los resultados podrán ayudar a los investigadores a comprender mejor la PAD y otras enfermedades del corazón y de los vasos sanguíneos. Los participantes deben tener al menos 2 años. Las mujeres que estén embarazadas no podrán participar en algunas actividades del estudio. Este estudio se lleva a cabo en Bethesda (Maryland).

Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular Diseases

Recruiting
All Ages
All Genders
Accepting Healthy Volunteers
Would you like to help researchers understand how rare genetic problems may lead to cardiovascular and vascular diseases? This study will collect blood, saliva, and tissue samples to study the underlying causes of diseases. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Natural History Study of CADASIL

Recruiting
Adult, Older Adult
All Genders
Accepting Healthy Volunteers
Do you have cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) or want to help someone with the condition? This study aims to learn more about a rare genetic disease called CADASIL. This condition causes small blood vessels in the body to become narrow, which can block blood flow to the brain and lead to a stroke. The study includes blood, urine, and imaging tests. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Featured Publications

NT5E mutations and arterial calcifications.

Authors: St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M
N. Engl. J. Med. 2011 Feb 03;364(5):432-42
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Early-onset stroke and vasculopathy associated with mutations in ADA2.

Authors: Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM,
N Engl J Med 2014 Feb 06;370(10):911-20
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Activated STING in a vascular and pulmonary syndrome.

Authors: Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim
N Engl J Med 2014 Jul 07;371(6):507-18
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TGF- β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.

Authors: Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M
Sci Transl Med 2014 Feb 12;6(227):227ra34
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Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome.

Authors: Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G
J Clin Invest. 2020 Aug 03;130(8):4167-4181
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Meet the Team

manfred

Manfred Boehm, M.D.

Senior Investigator

Manfred Boehm received his M.D. in 1993 from the University of Heidelberg, Germany and did his residency in internal medicine at the Franz-Volhard-Clinic, Berlin. Before arriving at the NIH and NHLBI, he was a research fellow at the Max Delbrück Center for Molecular Medicine, Berlin from 1996 to 1997, and the University of Michigan, Ann Arbor from 1997 to 1999. He joined NHLBI as a research fellow in 1999 and has been an Investigator since 2003. Dr. Boehm received a Foundation for Advanced Education in the Sciences Award for Research Excellence from the NIH. He was also the recipient the NHLBI Science Awards in 2015 for his team’s research on rare inherited vascular diseases in children. Since 2018, Dr. Boehm has been the Branch Chief of the NHLBI Translational Vascular Medicine Branch, which focuses on studying vascular disease mechanisms to develop novel treatment strategies to better serve our patients with vascular diseases through genomic and molecular high throughput approaches to help understand diseases processes in common and rare inherited disease populations.

Marta

Marta Cardenas

Patient Care Coordinator
Katherine

Katherine Carney, RN, BSC, CCRC

Research Nurse Specialist
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Cornelia Cudrici, M.D.

Assistant Research Physican
Zambia

Zambia Davis

Administrative Assistant
Elisa

Elisa Ferrante, Ph.D.

Staff Scientist
Jacob

Jacob Furcolo

Postbaccalaureate IRTA Fellow
Rebecca

Rebecca Harper, Ph.D.

Postdoctoral Visiting Fellow
Rebecca

Rebecca Huffstutler, CRNP

Family Nurse Practioner
Delong

Delong Liu, M.D.

Staff Scientist
Atul

Atul Mehta, M.D.

Critical Care Fellow
Keron

Keron Navarengom, M.D.

Special Volunteer
Doug

Douglas Rosing, M.D.

Senior Research Physician
Quan

Quan Yu, M.S.

Biologist
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Videos

NHLBI Orloff Award 2015: Manfred Boehm

Premature CAD Patient