Applied Precision Omics

The Laboratory of Applied Precision Omics, led by Dr. Sean Agbor-Enoh, aims to develop novel approaches to detect and treat lung transplant rejection.

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Clinical Trials and Studies

Genome Transplant Dynamics

Recruiting
All Ages
All Genders
Not Accepting Healthy Volunteers
Are you in need of a heart or lung transplant or have you had one in the past 3 months? Have you undergone a lung or heart transplant in the past 3 months or are you a candidate for heart or lung transplant? Some people with advanced heart and lung disease have heart and lung transplants but these new organs are often rejected. When this happens, patients must have repeated biopsies, which are invasive and expensive. Researchers in this clinical study want to see if a blood test can predict organ rejection and take the place of biopsies. To participate, you must be 18 to 80 years old and be a candidate for heart or lung transplant or have had a heart or lung transplant no more than three months ago. The study is taking place in Bethesda, Maryland, at the NIH Clinical Center, as well as in Baltimore, Maryland, and Falls Church, Virginia.

Featured Publications

Cell-free DNA maps COVID-19 tissue injury and risk of death, and propagates tissue injury.

Authors: Andargie TE, Tsuji N, Seifuddin F, Jang MK, Yuen PS, Kong H, Tunc I, Singh K, Charya A, Wilkins K, Nathan S, Cox A, Pirooznia M, Star RA, Agbor-Enoh S.
JCI Insight. 2021 Apr 08;6(7):e147610
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Cell-free DNA to detect heart allograft acute rejection.

Authors: Agbor-Enoh S, Shah P, Tunc I, Hsu S, Russell S, Feller E, Shah K, Rodrigo ME, Najjar SS, Kong H, Pirooznia M, Fideli U, Bikineyeva A, Marishta A, Bhatti K, Yang Y, Mutebi C, Yu K, Kyoo Jang M, Marboe C, Berry GJ, Valantine HA; GRAfT Investigators.
Circulation. 2021 Mar 23;143(12):1184-1197
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The SIRPα-CD47 immune checkpoint in NK cells.

Authors: Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S.
J Exp Med. 2021 Mar 01;218(3):e20200839.
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De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.

Authors: Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S
Nat Biotechnol. 2019 Oct 01;37(20):1137-1144
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Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation.

Authors: Agbor-Enoh S, Wang Y, Tunc I, Jang MK, Davis A, De Vlaminck I, Luikart H, Shah PD, Timofte I, Brown AW, Marishta A, Bhatti K, Gorham S, Fideli U, Wylie J, Grimm D, Goodwin N, Yang Y, Patel K, Zhu J, Iacono A, Orens JB, Nathan SD, Marboe C, Berry GJ, Quake
EBioMedicine. 2019 Feb 01;40:541-553
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Meet the Team

photo of Dr. Sean Agbor

Sean Agbor-Enoh, M.D., Ph.D.

Lasker Clinical Research Fellow, NIH Distinguished Scholar

Dr. Sean Agbor was born and raised in Cameroon, Central Africa. He received his M.D. at the University of Yaounde, Cameroon, after which, through a Fogarty International Center Scholarship, he travelled to Georgetown University Medical Center, Washington DC. There, he completed his Ph.D. and post-doctoral training in Molecular Biology followed by Internal Medicine internship and residency at Johns Hopkins Bayview Medical Center. He also served as Chief Resident in Internal Medicine before completing a joint fellowship in Pulmonary and Critical Care Medicine at the NIH Clinical Center and Johns Hopkins Hospital. He then accepted a clinician scientist position in Dr. Hannah Valantine’s Lab at the NHLBI before applying for and receiving the NIH-Lasker Clinical Research Fellow Award and NIH Distinguish Scholar Award. Currently, he has a joint appointment as a tenure-track investigator at NHLBI Pulmonary Branch and as a lung transplant pulmonary physician at the Johns Hopkins Hospital. His Laboratory of Applied Precision Omics (APO) is based at NHLBI and aims to develop novel approaches to detect and treat transplant rejection.

Follow the lab on Twitter at @AgborOmicsLabs.

hannah

Hannah Valantine, M.D.

Collaborator
headshot of Argit Marishta

Argit Marishta

Collaborator
headshot of Kenneth Bhatti

Kenneth Bhatti

Collaborator

Irina Kosinski

Collaborator
headshot of Joelle Khoriaty

Joelle Khoriaty

Collaborator
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